Sutariya, Tushar R. published the artcileA domino synthetic approach for new, angular pyrazol- and isoxazol-heterocycles using [DBU][Ac] as an effective reaction medium, Quality Control of 1076-59-1, the publication is RSC Advances (2015), 5(30), 23519-23529, database is CAplus.
The synthesis of pyrazole and isoxazole based heterocycles, e.g., I and II (R = H, Cl), via domino Knoevenagel-hetero-Diels-Alder (DKHDA) reaction of O-alkenylated acetophenones with active methylene pyrazolones and 3-phenyl-1,2-oxazol-5-one, resp., in an ionic liquid [DBU][Ac], effectively at 130 °C were described. The DKHDA reaction of O-alkynylated acetophenones is also feasible with 3-phenyl-1,2-oxazol-5-one but in the presence of ZnO as catalyst because it contains the unactivated dienophile moiety. The heterosteroid-mimicking structure II (R = H, Cl) thus achieved may have different bioprofiles than the aldehyde-derived one. The use of recyclable ionic liquid in place of organic solvents in the present method offers both ecol. and environmental benefits. The stereochem. of synthesized compounds was confirmed by the single crystal X-ray diffraction data.
RSC Advances published new progress about 1076-59-1. 1076-59-1 belongs to isoxazole, auxiliary class Oxazoline,Benzene,Ester, name is 3-Phenylisoxazol-5(2H)-one, and the molecular formula is C9H11BO4, Quality Control of 1076-59-1.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem