Wang, Yu published the artcileAnalgesic effect of parecoxib sodium and tramadol in painless induced abortion, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, the publication is Sichuan Yixue (2015), 36(1), 100-102, database is CAplus.
Objective: To compare the effect of parecoxib sodium and tramadol in combination with propofol on postoperative analgesia in painless induced abortion. Methods: 120 Cases of pregnant women of ASA I-II grade undergoing painless induced abortion were randomly divided into three groups. P group was preoperatively injected with 40 mg of parecoxib sodium, Q group was preoperatively injected with 100 mg of tramadol, and X group was preoperatively injected with 40 mg of parecoxib sodium and 100 mg of tramadol, and all groups were treated with 1.5-2.5 mg/kg propofol for anesthesia. The intraoperative consumption of propofol, intraoperative and postoperative analgesic effect and adverse reactions in the three groups were compared. Results: The intraoperative consumption of propofol in X group was significantly lower than that in P group and Q group (P < 0.05). All groups have good intraoperative analgesic effect without statistically significant difference (P > 0.05). The uterine contraction pain VAS scores at each time point during surgery in X group were significantly lower than those in P group and Q group, with statistically significant differences (P < 0.05). The difference of incidence of nausea and vomiting between the three groups was not statistically significant (P > 0.05). Conclusion: Application of parecoxib sodium combined with tramadol in painless induced abortion can reduce the intraoperative consumption of propofol, and has better efficacy than simple parecoxib sodium or tramadol.
Sichuan Yixue published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C8H14O2, Name: Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem