Zhou, Xiao-dao published the artcileInfluence of parecoxib Na on anesthesia recovery period of patients under the fast track anesthesia with remifentanil, Product Details of C19H17N2NaO4S, the publication is Zhongguo Linchuang Yaolixue Zazhi (2015), 31(9), 708-711, database is CAplus.
Objective To investigate the effects of preoperative use of parecoxib Na during anesthesia recovery period on the fast track anesthesia with remifentanil. Methods A total of 105 cases who received laparoscopic cholecystectomy were randomly divided into three groups with 35 cases in each group. Patients in group A received parecoxib Na 40 mg dissolved in normal saline 10 mL through injection 20 min before induction of anesthesia. Patients in group B received parecoxib Na 40 mg dissolved in normal saline10 mL through injection 20 min before the end of surgery. Patients in group C received normal saline 10 mL through injection 20 min before induction of anesthesia. The data of mean arterial pressure (MAP), heart rate (HR) and oxygen saturation (SPO2), verbal rating scale (VRS), sedation-agitation scale (SAS), Ramsay sedation scale (RSS) and comfort score (BCS) were compared among three groups. Results The data of MAP, SAS and HR in group A and group B were significantly lower than those in group C, and the data of MAP, SAS and HR in group A were significantly lower than those in group B (P<0.05). The data of RSS in group A was significantly lower than that in group B and RSS in group A and group B significantly higher than those in group C from T2 to T4 (P<0.05). The data of VRS in group A and group B were significantly lower than those in group C, and that in group A was significantly lower than group B each time point (P<0.05). Postoperative BCS in group A and group B were significantly higher than those in group C, and that in group A was significantly higher than group B (P<0.05). Conclusion Preoperative use of parecoxib Na could significantly reduce the acute pain of the fast track anesthesia with remifentanil, effectively inhibiting hyperalgesia and reducing the patient’s agitation.
Zhongguo Linchuang Yaolixue Zazhi published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C12H9N3O4, Product Details of C19H17N2NaO4S.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem