Qiu, Shuang published the artcileEffect of preemptive analgesia with parecoxib sodium combined with sufentanil postoperative analgesia on early cognitive function in elderly patients after operation, Application In Synthesis of 198470-85-8, the publication is Shiyong Yaowu Yu Linchuang (2016), 19(4), 425-429, database is CAplus.
To investigate the effect of preemptive analgesia with parecoxib sodium combined with sufentanil analgesia on postoperative cognitive function in elderly patients undergoing thoracic surgery. Sixty ASA I-II patients aged 65-75 years undergoing lung resection were randomly divided into two groups: parecoxib group (n = 30) and control group (n = 30). Parecoxib sodium (40 mg) + normal saline (5 mL) was injected i.v. after anesthesia induction in parecoxib group. Same volume saline was injected i.v. after anesthesia induction in control group. Patient-controlled i.v. analgesia with sufentanil 2 μg/kg and ramosetron hydrochloride 0.6 mg was used. At 2 h, 12 h and 24 h after operation, the pain score was evaluated by VAS score which should be less than 3. If VAS score was greater than 3, a bolus of PCIA was allowed until the analgesia was relieved. Cognitive function was assessed by Mini-Mental state examination (MMSE) at 1 d before operation and 2 h, 12 h and 24 h after operation. The total amount of sufentanil was recorded. Compared with control group, the incidence of postoperative cognitive dysfunction in parecoxib group was lower (P < 0.05), and the MMSE scores at 2 h, 12 h and 24 h after operation decreased more significantly (P < 0.05). The PCIA number of patients after compression in parecoxib group was less than that of control group with lower total amount of sufentanil and VAS score at 2 h, 12 h and 24 h after operation (P < 0.05). The incidence of adverse reaction (such as respiratory depression, nausea and vomiting) in parecoxib group was lower than that of control group (P < 0.05). Parecoxib sodium preemptive analgesia combined with sufentanil postoperative analgesia can effectively relieve the postoperative pain of elderly patients undergoing lung resection. Parecoxib sodium preemptive analgesia can reduce the risk of early period POCD and postoperative sufentanil consumption, and decrease the incidence of adverse reaction.
Shiyong Yaowu Yu Linchuang published new progress about 198470-85-8. 198470-85-8 belongs to isoxazole, auxiliary class Immunology/Inflammation,COX, name is Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide, and the molecular formula is C19H17N2NaO4S, Application In Synthesis of 198470-85-8.
Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem