Markgraf, J. Hodge’s team published research in Journal of Organic Chemistry in 29 | CAS: 2251-79-8

Journal of Organic Chemistry published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Safety of 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole.

Markgraf, J. Hodge published the artcileThe thermolysis of 5-aryl tetrazoles, Safety of 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, the publication is Journal of Organic Chemistry (1964), 29(9), 2629-32, database is CAplus.

Rates of the thermal decomposition of 5-phenyltetrazole (I) in several solvents and of 5-aryl tetrazoles in PhCN were measured by a precise technique over the range of 180-185°. Solvent effects caused significant differences in rate which were consistent with a competing ionization of I. Substituent effects led to only a small variation of rate. Although activation enthalpies and entropies varied widely, they acted in a compensatory manner. There were no satisfactory correlations by substituent constants Product analyses, studies with Na 5-phenyltetrazolide, and conductance measurements were carried out. The overall behavior is consistent with the generation of a benzonitrile imine intermediate.

Journal of Organic Chemistry published new progress about 2251-79-8. 2251-79-8 belongs to isoxazole, auxiliary class Trifluoromethyl,Fluoride,Benzene, name is 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole, and the molecular formula is C8H5F3N4, Safety of 5-(4-(Trifluoromethyl)phenyl)-1H-tetrazole.

Referemce:
https://en.wikipedia.org/wiki/Isoxazole,
Isoxazole | C3H3NO – PubChem