Matuszak, Nicolas; Es Saadi, Bouazza; Labar, Geoffray; Marchand-Brynaert, Jacqueline; Lambert, Didier M. published the artcile< Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: Investigation of the target residues and comparison with octhilinone>, COA of Formula: C7H5NO2, the main research area is benzisothiazolinone preparation monoacylglycerol lipase inhibitor.
The regulation of 2-arachidonoylglycerol (2-AG) levels is a major issue as 2-AG has been proven to participate in numerous physiopathol. phenomena such as neuroprotection or analgesia. Octhilinone, a cysteine-reagent compound, has recently been shown to inhibit in the nanomolar range monoacylglycerol lipase (MAGL), the major enzyme responsible for the degradation of 2-AG. Here, we further investigate the mechanism by which octhilinone and its benzisothiazolinone analog inhibit human MAGL. We also provide new information on the structural requirements for MAGL inhibition by these compounds Finally, we describe for N-octylbenzisothiazolinone a mode of inhibition which is partially different from that described for octhilinone, especially with regard to the targeted cysteine residues in the vicinity of the catalytic site.
Bioorganic & Medicinal Chemistry Letters published new progress about Alkylation. 21725-69-9 belongs to class isoxazole, and the molecular formula is C7H5NO2, COA of Formula: C7H5NO2.
Referemce:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem