With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.325744-41-0,5-(Chloromethyl)-3-(4-methoxyphenyl)isoxazole,as a common compound, the synthetic route is as follows.
325744-41-0, General procedure: To a stirred solution of ?a? derivatives in freshly distilled CH2Cl2 under N2 atmosphere, at roomtemperature, thionyl chloride (1.5 eq) was added. The reactions were monitored by TLC and, at thetotal consumption of the starting material, they were quenched with cold water and extracted withCH2Cl2. Next, the crude products were solubilized in DMF followed by addition of sodium azide (1.5eq). The reactions were kept at room temperature until TLC analyses indicated the disappearance ofthe starting material, then, they were quenched with water and extracted with EtOAc. In the last step,the crude azide derivatives were solubilized in THF followed by addition of triphenylphosphine (1.5 eq).The reactions were maintained overnight at room temperature, quenched by addition of aqueousNa2CO3 [5% (m/v)] and extracted with EtOAc. The crude amine derivatives (compound d) were usedfor the synthesis of the isoxazolyl-sulfonamide derivatives 1-20 without any further purification.
The synthetic route of 325744-41-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; da Rosa, Rafael; Zimmermann, Lara Almida; de Moraes, Milene Hoeehr; Schneider, Naira Fernanda Zanchett; Schappo, Alice Duarte; Simoes, Claudia Maria de Oliveira; Steindel, Mario; Schenkel, Eloir Paulo; Bernardes, Lilian Sibelle Campos; Bioorganic and Medicinal Chemistry Letters; vol. 28; 20; (2018); p. 3381 – 3384;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem