Application In Synthesis of 2-Chloropyridine 1-oxide. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Chloropyridine 1-oxide, is researched, Molecular C5H4ClNO, CAS is 2402-95-1, about Reaction of chloropyridine N-oxides with potassium amide in liquid ammonia.
2-Chloropyridine 1-oxide forms 2-aminopyridine 1-oxide (m. 163-4°) and 3-aminopyridine 1-oxide (m. 119-20°), though in a low yield, on treatment with liquid NH3 in the presence of KNH2. Under the same conditions, 3- and 4-chloropyridine 1-oxides give only the 3- and 4-amino compound (m. 64 and 154-5°, resp.), resp. Thus, the mechanism of these reactions is entirely the reverse of that of chloropyridine reported by Hertog (Pieterse and H., CA 58, 11325a; Martens and H., CA 58, 7902a); that of the 2-chloro compound is a benzyne mechanism and that of the 3- and 4-chloro compounds is an amination by an SN2 mechanism.
After consulting a lot of data, we found that this compound(2402-95-1)Application In Synthesis of 2-Chloropyridine 1-oxide can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem