With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21169-71-1,Isoxazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.
Example Llsoxazole-5-carboxylic acid [2-(2-o-tolyl-chroman-6-yloxy)-thiazol-5-ylmethyl]-amideTo a solution of [2-(2-o-tolyl-chroman-6-yloxy)-thiazol-5-ylmethyl]amine (150 mg, 0.43 mmol) in DMF (2 ml), 1 -(3-dimethylaminopropyl)-3-ethylcarbodiimidehydrochloride (1 14 mg, 0.60 mmol, 1 .4 eq), 1 -hydroxy-benzotriazole (81 mg, 0.60 mmol, 1 .4 eq) and N-methylmorpholine (107 mg, 1 .07 mmol, 2.5 eq) and isoxazole-5- carboxylic acid (72 mg, 0.64 mmol, 1 .5 eq) were added. The mixture was stirred for 16 h, then diluted with water, and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with a diluted aqueous solution of sodium carbonate and brine, dried over sodium sulfate and filtered, and the solvent was removed under reduced pressure. The crude product was purified by column chromatography (silica gel, ethyl acetate/methanol gradient), lsoxazole-5-carboxylic acid [2-(2-o-tolyl-chroman-6-yloxy)-thiazol-5-ylmethyl]-amide (1 12 mg, 59%) was obtained as a white solid.
21169-71-1, The synthetic route of 21169-71-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SANOFI; CZECHTIZKY, Werngard; WESTON, John; RACKELMANN, Nils; PODESCHWA, Michael; ARNDT, Petra; WIRTH, Klaus; GOEGELEIN, Heinz; RITZELER, Olaf; KRAFT, Volker; BELLEVERGUE, Patrice; McCort, Gary; WO2013/37724; (2013); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem