With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108511-97-3,Isoxazol-4-amine,as a common compound, the synthetic route is as follows.
Will be equipped with a stir bar,A 250 mL round bottom flask of the Dean-Stark trap and reflux condenser was removed from the oven.Cooling under vacuum,And backfill with argon.Under argon flow,Toluene (100 mL),(Structural formula is as follows) Compound 6 synthesized(11.91g, 19.82mmol),4-aminoisoxazole (1.665 g, 19.82 mmol) and p-toluenesulfonic acid monohydrate (1-2 mol%) were introduced into the reaction flask.Then reflux under stirring,A certain amount (about 0.36 g) of water was collected up to the bottom of the Dean-Stark trap.The reaction mixture was then filtered through celite.And evaporate volatile organic compounds,It is then distilled by Kugelrohr (boiling point is 105 C pressure of about 1 mTorr)Yielded 9.68 g of product(E)-6-(tert-butyl)-2-(1-(3-(isoxazol-4-yl)imino)butyl)-2,5-diisopropyl-4-phenyl- Synthesis of 1H-pyrrole-3-carboxamido)benzo[b]thiophene-3-carboxylic acid ethyl ester (Compound 7),Is a yellow crystal,The yield was 73.2%., 108511-97-3
The synthetic route of 108511-97-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Li Huaxu; (8 pag.)CN108191845; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem