1202769-66-1, 2-(5-Methylisoxazol-3-yl)but-3-yn-2-ol is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 2: A mixture of 66 (200 mg, 0.49 mmol, 1.00 equiv, 95%), 2-(5-methyl-l,2-oxazol-3-yl)but-3-yn-2- ol (200 mg, 1.32 mmol, 2.70 equiv), (PPh3)2Pd(II)Cl2 (350 mg, 0.50 mmol, 1.02 equiv) and TEA (2 mL) in DMSO (3 mL) was stirred under nitrogen at 70 C for 2 h. The reaction mixture was cooled to RT and loaded onto a C18 column. The column was eluted with acetonitrile/water (5:95 ~ 80:20) to afford 88 mg (38%) of ( 1 -(2-aminopyrimidin-4-yl)-6-(3-hydroxy-3-(5-methylisoxazol-3-yl)but- 1 -yn- 1 -yl)-lH- benzo[d]imidazol-2-yl)(pyrrolidin-l -yl)methanone as a light yellow solid. FontWeight=”Bold” FontSize=”10″ H NMR (300 MHz, DMSO- d6) delta 8.42 (d, 7 = 5.1Hz, 1H), 7.86 (s, 1H), 7.79 (d, 7 = 8.4Hz, 1H), 7.41 (d, 7 = 8.7Hz, 1H), 7.03 (s, 2H), 6.74 (d, 7 = 5.1Hz, 1H), 6.50 (s, 1H), 6.36 (s, 1H), 3.61 (d, 7 = 6.6Hz, 2H), 3.48 (d, 7 = 6.6Hz, 2H), 2.40 (s, 3H), 1.92 (s, 4H), 1.80 (s, 3H); LC-MS: m z= 458 (M+H)+., 1202769-66-1
As the paragraph descriping shows that 1202769-66-1 is playing an increasingly important role.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; HOEFLICH, Klaus P.; LYLE, Karen S.; STABEN, Steven; WO2014/170421; (2014); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem