Kramer, Rainer; Lang, Rudolph; Brzezinski, Bogumil; Zundel, Georg published an article about the compound: 1-Piperidineacetic Acid( cas:3235-67-4,SMILESS:OC(=O)CN1CCCCC1 ).Recommanded Product: 3235-67-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3235-67-4) through the article.
1-Piperidinecarboxylic acids C5H10N(CH2)nCO2H (I; n = 1-4) solutions have been studied by NMR and IR as well as osmometric measurements. NMR shows that with I relatively strong intramol. hydrogen bonds are formed. The osmometric measurements demonstrate that I (n = 4) is always dimerized owing to dipole-dipole interactions. At low concentrations in relatively polar solvents the I (n = 2) is present as a monomer. With increasing concentration it also dimerizes. Because of this dimerization the equilibrium is shifted in favor of the zwitterionic polar structure. In the case of I (n = 4), from temperature-dependent measurements the enthalpy ΔH° and the entropy ΔS° have been determined with two solvents. Both quantities are large and neg., in agreement with all other systems with AH…B⇋A-…H+B equilibrium studied up to now. For the I (n = 4) the strong influence of the CH acidity of the solvent is illustrated. This specific interaction effect is responsible for the double min. in the proton potential.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem