The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Chloropyridine 1-oxide( cas:2402-95-1 ) is researched.Application In Synthesis of 2-Chloropyridine 1-oxide.Li, Chuan-chuan; Zheng, Zhan-chao; Zhou, Yan; Zhang, Chuan-hao; Zhan, Jia-rong published the article 《Synthesis of ZPT as a broad-spectrum fungicide》 about this compound( cas:2402-95-1 ) in Huaxue Shiji. Keywords: ZPT preparation fungicide; chloropyridine oxidation thiolation. Let’s learn more about this compound (cas:2402-95-1).
In the oxidation catalytic system of maleic anhydride and acetic acid, 2-chloropyridine is converted to ZPT as a raw material. Controlling the thiolation reaction by Na2S-NaSH buffer system, the overall yield is about 75%. The route is suitable for industrial production due to low cost, easy preparation, low risk and high yield.
In some applications, this compound(2402-95-1)Application In Synthesis of 2-Chloropyridine 1-oxide is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem