Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloropyridine 1-oxide, is researched, Molecular C5H4ClNO, CAS is 2402-95-1, about Carbon-13 nuclear magnetic resonance spectra of substituted pyridine N-oxides.Safety of 2-Chloropyridine 1-oxide.
13C NMR spectra of substituted pyridine N-oxides were examined and compared to the spectra of the corresponding free pyridine bases. The N-oxide functionality causes significant shielding at the C-2, C-4, and C-6 positions. This shielding was associated with electron d. donation by the N-oxide functionality to these positions. The N-oxide functionality also caused an enhancement of the substituent α-effect for -NMe2, -OMe, and -NO2 groups.
As far as I know, this compound(2402-95-1)Safety of 2-Chloropyridine 1-oxide can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem