Anuszewska, E. L.; Koziorowska, J. H. published an article about the compound: 2-Chloropyridine 1-oxide( cas:2402-95-1,SMILESS:ClC1=CC=CC=[N+]1[O-] ).SDS of cas: 2402-95-1. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2402-95-1) through the article.
The nature of biol. effects of substituted pyridines and their N-oxides is a matter for discussion. The previous study demonstrated that 3-chlopyridine is cytotoxic and clastogenic. No cytotoxic activity was observed with 2-chloropyridine tested in the same dose range. In this study experiments were performed to assess cytotoxicity and clastogenicity of 2-chloropyridine N-oxide and 3-chloropyridine N-oxide. In the dose range from 800 to 3200 μg 2-chloropyridine/mL, N-oxide showed a dose-dependent cytotoxicity and clastogenicity. In the same dose range, 3-chloropyridine N-oxide was found to be non-cytotoxic and non-clastogenic. The nature of the effects induced by 3-chloropyridine and 2-chloropyridine N-oxide was analyzed on the basis of possible protection by scavengers of reactive oxygen species. The cytotoxicity of both compounds was effectively suppressed by catalase and hydroxyl radicals scavengers. Pretreatments of V3 cells with DMSO or catalase provided protection against the ability of both compounds to induce chromosomal aberrations. From the data of this study the authors conclude that cytotoxicity and clastogenicity of 3-chloropyridine and 2-chloropyridine N-oxide are linked to the generation of reactive oxygen species.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem