Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2402-95-1, is researched, SMILESS is ClC1=CC=CC=[N+]1[O-], Molecular C5H4ClNOJournal, Article, Research Support, Non-U.S. Gov’t, Angewandte Chemie, International Edition called Bronsted Acid-Catalyzed Oxygenative Bimolecular Friedel-Crafts-type Coupling of Ynamides, Author is Patil, Dilip V.; Kim, Seung Woo; Nguyen, Quynh H.; Kim, Hanbyul; Wang, Shan; Hoang, Tuan; Shin, Seunghoon, the main research direction is ynamides nucleophilic arene oxygenative bimol Friedel Crafts type coupling; Brønsted acid catalysis; intermolecular trapping; pyridine-N-oxides; ynamides; α-oxo carbene surrogate.Computed Properties of C5H4ClNO.
A non-metal approach for accessing α-oxo carbene surrogates for a C-C bond-forming bimol. coupling between ynamides and nucleophilic arenes was developed. This acid-catalyzed coupling features mild temperature, which is critical for the required temporal chemoselectivity among nucleophiles. The scope of nucleophiles includes indoles, pyrroles, anilines, phenols and silyl enolethers to afford the corresponding functionalized products, e.g., I. Furthermore, a direct test of SN2′ mechanism has been provided by employing chiral N,N’-dioxides which also enlightens the nature of the intermediates in related metal-catalyzed processes.
Here is just a brief introduction to this compound(2402-95-1)Computed Properties of C5H4ClNO, more information about the compound(2-Chloropyridine 1-oxide) is in the article, you can click the link below.
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem