The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Piperidineacetic Acid( cas:3235-67-4 ) is researched.Quality Control of 1-Piperidineacetic Acid.Liu, Liang-Quan; Hong, Pei-Xi; Song, Xing-Hai; Zhou, Chang-Cui; Ling, Rui; Kang, Yi; Qi, Qing-Rong; Yang, Jun published the article 《Design, Synthesis, and Activity Study of Water-Soluble, Rapid-Release Propofol Prodrugs》 about this compound( cas:3235-67-4 ) in Journal of Medicinal Chemistry. Keywords: water solubility propofol prodrug pharmacodynamics solubility. Let’s learn more about this compound (cas:3235-67-4).
In this work, a series of water-soluble propofol prodrugs were synthesized, and their propofol release rate and pharmacodynamic characteristics were measured. We found that inserting glycolic acid as a linker between propofol and the cyclic amino acid accelerated the release of propofol from prodrugs into the plasma while preserving its safety. In animal experiments, prodrugs (3e, 3g, and 3j) were significantly better than fospropofol (the only water-soluble propofol prodrug that has been used clin.) in terms of safety, onset, and duration time of anesthesia. Their molar dose, onset time, and anesthesia duration time were comparable to those of propofol, helping to maintain the clin. benefits of propofol. The exptl. results showed the potential of such compounds as water-soluble prodrugs of propofol.
There is still a lot of research devoted to this compound(SMILES：OC(=O)CN1CCCCC1)Quality Control of 1-Piperidineacetic Acid, and with the development of science, more effects of this compound(3235-67-4) can be discovered.
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem