The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Piperidineacetic Acid(SMILESS: OC(=O)CN1CCCCC1,cas:3235-67-4) is researched.SDS of cas: 676-96-0. The article 《Search for anticholinergic compounds. XLV. Structure and pharmacological activity of some esters of alkylamino acids: piperidino-, morpholino-, dicyclohexylamino-, phenylcyclohexylamino-, diphenylamino-, benzylphenylamino-, and benzylcyclohexylaminoacetic acids》 in relation to this compound, is published in Acta Poloniae Pharmaceutica. Let’s take a look at the latest research on this compound (cas:3235-67-4).
The anticholinergic activity of a number of esters of acetic and aminoacetic acid derivatives was assessed as a function of the Schild index value. The highest activity was observed when piperidine was part of the alc. moiety and the acid moiety contained a branched substituent. With branched substituents in both the acid and the alc. moiety, activity decreased markedly. Aminoacetate esters were more active than the analogous acetate esters, the presence of 2 -O-C-C-N- groups in the mol. apparently being the reason behind this observation. 2-(1-Piperidinyl)ethyl diphenylaminoacetate [102964-41-0] was more active than pipethanate [4546-39-8].
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Reference:
Isoxazole – Wikipedia,
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