In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties, published in 2016-07-19, which mentions a compound: 84746-24-7, Name is 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine, Molecular C12H14N6, Application In Synthesis of 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine.
A series of novel carboxamide compounds containing piperazine and arylsulfonyl moieties, e.g., I, II and III have been synthesized. The bioassay results showed that some compounds exhibited favorable herbicidal activities against dicotyledonous plants and many of them possessed excellent antifungal activities. Among 24 novel compounds, some showed superiority over the com. fungicides Chlorothalonil, Dimethomorph, Thiophanate-Me, Iprodione, and Zhongshengmycin at 500 mg/L concentration Some compounds also exhibited high KARI inhibitory activity at 100 μg/mL concentration and could be used as new KARI lead inhibitors for further studies. Moreover, SAR of these new compounds were comprehensively investigated using different computational methods in which 3D-QSAR model obtained provided useful information for further structural optimization for the discovery of new fungicides. The results of this research will contribute to explore comprehensive biol. activities of piperazine containing compounds in different areas of chem.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem