The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Piperidineacetic Acid( cas:3235-67-4 ) is researched.Recommanded Product: 1-Piperidineacetic Acid.Mizumoto, Shinsuke; Xi, Siqi; Fujiwara, Yusuke; Kawashima, Shigehiro A.; Yamatsugu, Kenzo; Kanai, Motomu published the article 《Hydroxamic Acid-Piperidine Conjugate is an Activated Catalyst for Lysine Acetylation under Physiological Conditions》 about this compound( cas:3235-67-4 ) in Chemistry – An Asian Journal. Keywords: hydroxamic acid piperidine conjugate catalyst lysine acetylation physiol; acylation; catalyst; hydroxamic acid; lysine acetylation; protein modifications. Let’s learn more about this compound (cas:3235-67-4).
Lysine acylation of proteins is an essential chem. reaction for posttranslational modification and as a means of protein modification in various applications. N,N-Dimethyl-4-aminopyridine (DMAP) derivatives are widely-used catalysts for lysine acylation of proteins; however, the DMAP moiety mostly exists in a protonated, and thus deactivated, form under physiol. conditions due to its basicity. An alternative catalytic motif furnishing higher acylation activity would further broaden the possible applications of chem. lysine acylation. We herein report that the hydroxamic acid-piperidine conjugate Ph-HXA is a more active catalytic motif for lysine acetylation than DMAP under physiol. conditions. In contrast to DMAP, the hydroxamic acid moiety is mostly deprotonated under aqueous neutral pH, resulting in a higher concentration of the activated form. The Ph-HXA catalyst is also more tolerant of deactivation by a high concentration of glutathione than DMAP. Therefore, Ph-HXA might be a suitable catalytic motif for target protein-selective and site-selective acetylation in cells.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem