62348-13-4, Isoxazole-5-carbonyl chloride is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
62348-13-4, To a solution of the above material (0.300 g, 0.708 mmol) in CH2Cl2 (3 mL), isoxazole-5-carbonyl chloride (0.1024 g, 0.78 mmol) and triethylamine (0.13 mL, 0.92 mmol) were added. The resulting solution was stirred at room temperature overnight, and partitioned between CH2Cl2 and water. The organic extract was washed with brine, dried over Na2SO4, filtered and concentrated. The residue was subjected to silica gel chromatography eluted with 10-40% ethyl acetate in hexanes to provide the title compound that gave a proton NMR spectrum consistent with theory and a mass ion (ES+) of 519.3 for M+H+(35Cl): 1H NMR (300 MHz, MeOH-d4) delta 8.59 (s, 1H), 7.83 (d, J=5.6 Hz, 1H), 7.60 (q, J=8.0 Hz, 1H), 7.31-7.23 (m, 4H), 7.11 (s, 1H), 7.02 (d, J=8.1 Hz, 1 H), 6.69 (d, J=5.6 Hz, 1 H), 5.23 (q, J=6.8 Hz, 1H), 4.86 (s, 3H), 1.48 (d, J=7.0 Hz, 3H).
62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; Kuduk, Scott D.; Bock, Mark G.; Feng, Dong-Mei; Wai, Jenny Miu-Chun; US2004/29920; (2004); A1;,
Isoxazole – Wikipedia
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