In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Research on synthesis of 2-chloro-4-nitropyridine-N-oxide, published in 2012-08-25, which mentions a compound: 2402-95-1, mainly applied to chloronitropyridine oxide synthesis chloropyridine oxidation mixed acid nitrification, Recommanded Product: 2-Chloropyridine 1-oxide.
2-Chloro-4-nitropyridine-N-oxide was synthesized from 2-chloropyridine by N-oxidation and mixed acid nitrifying with one pot reaction. The intermediate yield of 2-chloropyridine-N-oxide was 96.5% when n(2-chloropyridine):n(H2O2):n(CH3COOH) = 1:3.5:1.5, the reaction temperature was 80°C and the reaction time was 3 h. Synthetic liquid proceeded nitration reaction directly after enrichment. The production yield of 2-chloro-4-nitropyridine-N-oxide was 85.8% when n(2-chloropyridine-N-oxide):n(HNO3) = 1:3.5, V(H2SO4)/V(HNO3) = 1:1, the reaction temperature was 80°C and the reaction time was 6 h. The structures of intermediate and target product were confirmed by M.p., IR, MS and elemental anal. The final product was gained.
This literature about this compound(2402-95-1)Recommanded Product: 2-Chloropyridine 1-oxidehas given us a lot of inspiration, and I hope that the research on this compound(2-Chloropyridine 1-oxide) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem