The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Methanesulfonato(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)palladium(II), is researched, Molecular C43H56NO5PPdS, CAS is 1445085-77-7, about Regioselective 2-Amination of Polychloropyrimidines, the main research direction is regioselective palladium catalyzed amination polychloropyrimidine arylamine heteroarylamine; amination trimethylsilyldichloropyrimidine surrogate; aminated thiomethoxypyrimidine preparation chlorothiomethoxy analog amination.Category: isoxazole.
The regioselective amination of substituted di- and trichloropyrimidines affording the 2-substituted products is reported. While aryl- and heteroarylamines require the use of a dialkylbiarylphosphine-derived palladium catalyst for high efficiency, more nucleophilic dialkylamines produce 2-aminopyrimidines under noncatalyzed SNAr conditions. The key is the use of 5-trimethylsilyl-2,4-dichloropyrimidine as a surrogate for the parent dichloropyrimidine. For more challenging cases, the 2-chloro-4-thiomethoxy analogs were prepared and exclusively afford the desired 2-aminated-4-thiomethoxypyrimidine products.
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Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem