59669-59-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59669-59-9,3-(tert-Butyl)isoxazol-5-amine,as a common compound, the synthetic route is as follows.
To a cold slurry of (S)-1-(4-Chloro-phenyl)-4-oxo-azetidine-2-carboxylic acid (0.2g; 1.037mmol) and 5-amino-3-tert-butylisoxazole (0.145g; 1.037mmol) in pyridine (1.258mL; 15.555mmol) is added phosphorous oxychloride (O.l lbetamL; 1.244mmol). The mixture is stirred at O¡ãC for 30 minutes and then diluted with water and extracted with ethyl acetate several times. The organics are combined and washed with water and brine, dried over Na2SO4, filtered and concentrated in vacuo. Purification by preparative HPLC affords title compound, m/z 348 [M+H+]
The synthetic route of 59669-59-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HICKEY, Eugene, Richard; RIETHER, Doris; THOMSON, David, Smith; WU, Lifen; ZINDELL, Renee, M.; WO2010/147791; (2010); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem