In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Bronsted Acid-Catalyzed Oxygenative Bimolecular Friedel-Crafts-type Coupling of Ynamides, published in 2017, which mentions a compound: 2402-95-1, mainly applied to ynamides nucleophilic arene oxygenative bimol Friedel Crafts type coupling; Brønsted acid catalysis; intermolecular trapping; pyridine-N-oxides; ynamides; α-oxo carbene surrogate, Application of 2402-95-1.
A non-metal approach for accessing α-oxo carbene surrogates for a C-C bond-forming bimol. coupling between ynamides and nucleophilic arenes was developed. This acid-catalyzed coupling features mild temperature, which is critical for the required temporal chemoselectivity among nucleophiles. The scope of nucleophiles includes indoles, pyrroles, anilines, phenols and silyl enolethers to afford the corresponding functionalized products, e.g., I. Furthermore, a direct test of SN2′ mechanism has been provided by employing chiral N,N’-dioxides which also enlightens the nature of the intermediates in related metal-catalyzed processes.
If you want to learn more about this compound(2-Chloropyridine 1-oxide)Application of 2402-95-1, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(2402-95-1).
Reference:
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem