With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3209-71-0,Isoxazole-3-carboxylic Acid,as a common compound, the synthetic route is as follows.
N-(2-(2-Phenylthiazol-4-yl)ethyl)isoxazole-3-carboxamide To a solution of the 2-(2-phenylthiazol-4-yl)ethan-1 -amine (80 mg, 0.39 mmol) in DMF (1 ml) was added the 1 ,2-oxazole-3-carboxylic acid (53 mg, 0.47 mmol), EDCI (91 mg, 0.47 mmol) and DMAP (5 mg, 0.04 mmol). The reaction mixture was stirred at 45 C for 18 h. Water (approximately 2 ml) was added to the reaction mixture and the product extracted with ethyl acetate (three times). The organic layers were combined and dried with magnesium sulphate. All of the volatiles were remove in vacuo and the crude material was purified by column chromatography, eluting with 10% ethyl acetate/petroleum spirit to obtain the desired product as a pale-orange oil (17 mg, 15%). LRMS [M+H]+ 300.1 m/z; HRMS [M+H]+ 300.0801 m/z, found 300.0802 m/z; 1 H NMR (400 MHz, DMSO) delta 9.08 (d, J = 1 .7 Hz, 1 H), 8.94 (t, J = 5.6 Hz, 1 H), 8.06 – 7.81 (m, 2H), 7.58 – 7.45 (m, 3H), 7.44 (s, 1 H), 6.88 (d, J = 1 .7 Hz, 1 H), 3.63 (dd, J = 13.1 , 7.2 Hz, 2H), 3.03 (t, J = 7.2 Hz, 2H).
3209-71-0, The synthetic route of 3209-71-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MONASH UNIVERSITY; THE UNIVERSITY OF WESTERN AUSTRALIA; BAELL, Jonathan; PIGGOTT, Matthew; RUSSELL, Stephanie; TOYNTON, Arthur; RAHMANI, Raphael; FERRINS, Lori; NGUYEN, Nghi; (178 pag.)WO2015/172196; (2015); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem