With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123770-62-7,Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.
Reference Production Example 195 (0838) Methanesulfonyl-chloride (5.42 mL, 38.90 mmol) was added to a chloroform solution (amylene addition product, 100 mL) of ethyl 5-hydroxymethylisoxazole-3-carboxylate (5.12 g, 29.92 mmol) and triethylamine (2.66 mL, 34.40 mmol) under ice-water cooling, and the mixture was stirred at room temperature or lower for 2 hours. Then, the mixture was poured into ice water, and extracted twice with chloroform. The organic layer was washed with saturated saline water, dried over magnesium sulfate and then concentrated under reduced pressure, and the residue was applied to a silica gel column chromatography to obtain 6.02 g of ethyl 5-methanesulfonyloxymethylisoxazole-3-carboxylate represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):1.43(3H, t)3.09(3H, s), 4.46(2H, q), 5.36(2H, s), 6.87(1H, s)., 123770-62-7
The synthetic route of 123770-62-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Isoxazole – Wikipedia
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