In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 1008-75-9, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1008-75-9, name is 3-Methyl-5-phenylisoxazole. In an article，Which mentioned a new discovery about 1008-75-9
The generation of gold carbenes via the gold-catalyzed intermolecular reaction of nucleophiles containing relatively labile N-O or N-N bonds with alkynes has received considerable attention during recent years. However, this protocol is not atom-economic as the reaction produces a stoichiometric amount of pyridine or quinoline waste, the cleaved part of the N-O or N-N bonds. In this article, we disclose an unprecedented gold-catalyzed formal [3+2] cycloaddition between ynamides and isoxazoles, allowing rapid and practical access to a wide range of synthetically-useful 2-aminopyrroles. Most importantly, mechanistic studies and theoretical calculations revealed that this reaction presumably proceeds via an alpha-imino gold carbene pathway, thus providing a strategically novel, atom-economic route to the generation of gold carbenes. Other significant features of this approach include the use of readily-available starting materials, high flexibility, simple procedure, mild reaction conditions, and in particular, no need to exclude moisture or air (“open flask”).
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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem