847490-69-1,847490-69-1, 4-Iodoisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Isopropyl magnesium chloride lithium chloride complex (2.62 ml, 3.41 mmol) was addeddropwise to 4-iodoisoxazole (0.609 g, 3.12 mmol) in THF (10 mL) at 0C and the mixture wasstirred for 1 h, during which time the temperature rose to 18C. A solution of methyl 3,3- dicyano-2-cyclopropylacrylate (see Step A of 1-19) (0.5 g, 2.84 mmol) in THF (3 mL) was added at 0C. The resulting mixture was allowed to rise to RT slowly and stirred for 4 h, then was quenched with ice-cold saturated aq. NH4C1 and extracted with EtOAc. The organic layer wasdried with Mg504, filtered, and concentrated in vacuo. Purification by silica gel column chromatography using a hexanes/EtOAc gradient (0-1 00%EtOAc/Hexane) afforded the title product. 1H NMR (500 MHz, CDC13): oe 8.74 (1H, s), 8.53 (1H, s), 4.59 (1H, s), 3.89 (3H, s),1.08 (1H, m), 0.91(2H, m), 0.61 (1H, m), 0.52 (1H, m), m/z=246.13 (M+1).
As the paragraph descriping shows that 847490-69-1 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; HAN, Xiaoqing; WHITEHEAD, Alan; RAGHAVAN, Subharekha; GROEPER, Jonathan; GUO, Jian; ZHANG, Yong; WO2015/88885; (2015); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem