Extracurricular laboratory:new discovery of 5-Methylisoxazole-3-carboxylic acid

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Quality Control of 5-Methylisoxazole-3-carboxylic acid. Introducing a new discovery about 3405-77-4, Name is 5-Methylisoxazole-3-carboxylic acid

The development of a novel protocol for the fast introduction of the picolinamide directing group in aliphatic ketones by using the ammonia-Ugi 4-CR reaction and the subsequent evaluation of the Pd-mediated gamma-C(sp3)-H bond activation is described. The methodology allows the efficient construction of a series of gamma-arylated alpha-aminoamides bearing a congested carbon in two steps.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Safety of 5-Methylisoxazole-3-carboxylic acid, you can also check out more blogs about3405-77-4

Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem