288-14-2, Name is Isoxazole, belongs to isoxazole compound, is a common compound. Computed Properties of C3H3NOIn an article, once mentioned the new application about 288-14-2.
Four polysaccharide based chiral stationary phases were chosen, two chlorinated: Lux Amylose-2 (tris-5-chloro-2-methylphenylcarbamate of amylose) and Lux Cellulose-2 (tris-3-chloro-4-methylphenylcarbamate of cellulose) and two methylated: Chiralpak AD-H (tris-3,5-dimethylphenylcarbamate of amylose) and Chiralcel OD-H (tris-3,5-dimethylphenylcarbamate of cellulose) to separate four 3-carboxamido-5-aryl isoxazole derivatives by supercritical fluid chromatography. The effect of chiral stationary phase, co-solvent nature (MeOH, EtOH, 2-PrOH and ACN) and percentage (10?20%), temperature (20?45 C) and chemical structure of the compounds on retention, resolution and elution order were thoroughly studied. In addition, thermodynamic parameters were determined from the linear portion of the Van’t Hoff plots. For all the derivatives, the Lux Cellulose-2 and Chiralpak AD-H provided excellent resolutions (Rs = 9.78) in short run time (under 6 min). The preparation of about 10 mg of each of the eight enantiomers was achieved successfully on a Chiralpak AD-H with various percentages of ethanol as a co-solvent. Lastly, the enantiomeric purity of each of the eight individual enantiomer generated was determined and found higher than 98%.
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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem