Electric Literature of 33282-15-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.33282-15-4, Name is 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid, molecular formula is C10H7NO4. In a Article，once mentioned of 33282-15-4
Accumulating evidence suggests that fibrinogen, a key protein in the coagulation cascade, plays an important role in circulatory dysfunction in Alzheimer’s disease (AD). Previous work has shown that the interaction between fibrinogen and beta-amyloid (Abeta), a hallmark pathological protein in AD, induces plasmin-resistant abnormal blood clots, delays fibrinolysis, increases inflammation, and aggravates cognitive function in mouse models of AD. Since Abeta oligomers have a much stronger affinity for fibrinogen than Abeta monomers, we tested whether amyloid aggregation inhibitors could block the Abeta-fibrinogen interaction and found that some Abeta aggregation inhibitors showed moderate inhibitory efficacy against this interaction. We then modified a hit compound so that it not only showed a strong inhibitory efficacy toward the Abeta-fibrinogen interaction but also retained its potency toward the Abeta42 aggregation inhibition process. Furthermore, our best hit compound, TDI-2760, modulated Abeta42-induced contact system activation, a pathological condition observed in some AD patients, in addition to inhibiting the Abeta-fibrinogen interaction and Abeta aggregation. Thus, TDI-2760 has the potential to lessen vascular abnormalities as well as Abeta aggregation-driven pathology in AD.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 33282-15-4
Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem