53983-15-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53983-15-6,Ethyl 5-amino-4-phenylisoxazole-3-carboxylate,as a common compound, the synthetic route is as follows.
5.0 g (23 mmol) of ethyl phenylcyanopyruvate were reacted according to the method described in Chem. Ber. 107 (1974) 2794-2795 and Ber. Deutsch. Chem. Ges. 33 (1900) 2592-2595. Whereby there was obtained in 69.7% yield ethyl 5-amino-4-phenyl-3-isoxazolecarboxylate as beige crystals which melted at 119-121 after recrystallization from ethyl acetate/hexane. 2.9 g (12.5 mmol) of ethyl 5-amino-4-phenyl-3-isoxazolecarboxylate were heated to 110 for 2 hours under reduced pressure with 5.0 g (31.2 mmol) of t-butyl (2-aminoethyl)carbamate, whereby the ethanol formed was distilled off continuously. The cooled reaction mixture was dissolved in methylene chloride and chromatographed on 100 g of silica gel. Elution with methylene chloride which contains 5%. 10% and, respectively, 20% of ethyl acetate, combining of the pure fractions and evaporation yielded 1.9 g of crystals. Recrystallization from ethyl acetate/hexane yielded 1.5 g (34.7%) of t-butyl [2-(5-amino-4-phenyl-3-isoxazolecarboxamido)ethyl]carbamate as white crystals, melting point 144.
The synthetic route of 53983-15-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Hoffmann-La Roche Inc.; US5011849; (1991); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem