3209-71-0, Isoxazole-3-carboxylic Acid is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Compound 3 (24.0 g) and 16.17 g of isoxazole-3-carboxylic acid were suspended in 288 mL of acetone, 49.36 g of pyridine was added thereto and the suspension was cooled to -10C. 31.89 g of phosphorus oxychloride was poured into the suspension to react at 20 +/- 10C for about 30 minutes. The reaction mixture was cooled to 5C or below, 5.3 mL of water was added dropwise to the mixture at 20C, and 355 mL of water was poured therein. Then, 10% sodium hydroxide aqueous solution was added dropwise to the mixture until pH 4.5, and the mixture was stirred at 15 +/- 10C for about 2 hours to precipitate crystals. The crystallized slurry obtained was filtered, and the crystals were washed sequentially with 48 mL of 10% aqueous acetone, 192 mL of water, and 72 mL of 10% aqueous acetone, and dried in vacuo to afford Compound 4 (33.24 g, 91.4%).
3209-71-0, 3209-71-0 Isoxazole-3-carboxylic Acid 11286453, aIsoxazoles compound, is more and more widely used in various fields.
Reference£º
Patent; SHIONOGI & CO., LTD.; EP1408041; (2004); A1;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem