3405-77-4, Name is 5-Methylisoxazole-3-carboxylic acid, belongs to isoxazole compound, is a common compound. Product Details of 3405-77-4In an article, once mentioned the new application about 3405-77-4.
Porcine epidemic diarrhea virus (PEDV) causes high mortality in pigs. PEDV main protease (Mpro) plays an essential role in viral replication. We solved the structure of PEDV Mpro complexed with peptidomimetic inhibitor N3 carrying a Michael acceptor warhead, revealing atomic level interactions. We further designed a series of 17 inhibitors with altered side groups. Inhibitors M2 and M17 demonstrated enhanced specificity against PEDV Mpro. These compounds have potential as future therapeutics to combat PEDV infection.
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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem