In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: Ethyl 5-methylisoxazole-4-carboxylate, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 51135-73-0, name is Ethyl 5-methylisoxazole-4-carboxylate. In an article，Which mentioned a new discovery about 51135-73-0
This invention describes a process for the preparation of N-(4-trifluoromethyl)-5-methylisoxazole-4-carboxamide commonly known as leflunomide comprising : (a) reacting ethylaceto acetate, triethylorthoformate, and acetic anhydride with simultaneous distillation to form ethyl ethoxymethyleneacetoacetic ester; (b) reacting the ethyl ethoxymethyleneacetoacetic ester with aqueous hydroxylamine without using any external base and without any distillation to form ethyl-5-methylisoxazole-4-carboxylate; (c) reacting the ethyl-5-methylisoxazole-4-carboxylate with strong acid to form -5-methylisoxazole-4-carboxylic acid; (d) 5-methylisoxazole-4-carboxylic acid is reacted with thionyl chloride in presence of N, N-Dimethylformamide and equimolar of 4-trifluoromethylaniline without any external base to obtain highly pure Leflunomide.
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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem