With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1136-45-4,5-Methyl-3-phenylisoxazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.
A solution of 5-methyl-3-phenylisoxazole-4-carboxylic acid (60 mg, 0.3 mmol), DIEA (46 mg, 0.36 mmol), and DPPA (100 mg, 0.38 mmol) in toluene (1 mL) was shaken for 30 minutes at room temperature and then heated and shaken at 90 C for 16 h. The reaction mixture was then added to the resin from step A and mixture shaken for 5 h at 90 C. The reaction mixture was filtered and the resin was washed with 3 times each with DMF, 1 : 1 acetic acid/DCM, water, isopropanol and finally with DCM. The resin was then dried in a vacuum oven for 2 h., 1136-45-4
1136-45-4 5-Methyl-3-phenylisoxazole-4-carboxylic acid 14343, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; COOKE, Andrew, J.; STUMP, Craig, A.; ZHANG, Xu-Fang; LI, Chun Sing; MAO, Qinghua; WO2015/42085; (2015); A2;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem