33282-15-4, Name is 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid, belongs to isoxazole compound, is a common compound. Recommanded Product: 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acidIn an article, once mentioned the new application about 33282-15-4.
A detailed examination of the synthesis of functionalized 6,11-dihydro-5H-benzo[b]pyrimido[5,4-f]azepines 4 is described. Base-promoted aromatic nucleophilic substitution of 5-allyl-4,6-dichloropyrimidines 1a-c with different N-substituted anilines and indoline gave the corresponding aminolysis products 3a-p, which on acid-promoted intramolecular Friedel-Crafts cyclization produced the target polysubstituted 6,11-dihydro-5H-benzo[b]pyrimido[5,4-f]azepines 4a-p in moderate to very high yields. An efficient two-step protocol to access a new series of polysubstituted 6,11-dihydro-5H-benzo[b]pyrimido[5,4-f]azepines from readily available 5-allyl-4,6-dichloropyrimidines is described for the first time.
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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem