With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2510-36-3,3,5-Dimethylisoxasole-4-carboxylic acid,as a common compound, the synthetic route is as follows.
Example 219 3,5-Dimethyl-isoxazole-4-carboxylic acid [4-chloro-5-(l-methyl-2-oxo-l,2,3,4- tetrahydro-quinolin-6-yl)-pyridin-3-ylmethyl]-amideTo a solution of 6-(5-aminomethyl-4-chloro-pyridin-3-yl)-l-methyl-3,4-dihydro-lH- quinolin-2-one hydrochloride (example 218, 0.05 g, 0.148 mmol) in dry DMF (1 mL) were added EDCI (0.034 g, 0.077 mmol), hydroxybenzotriazole (0.017 g, 0.077 mmol), Hunig’s base (0.057 g, 0.443 mmol) and 3,5-dimethyl-isoxazole-4-carboxylic acid (0.021 g, 0.148 mmol) and the resulting solution was stirred at room temperature for 2h. The reaction mixture was diluted with EtOAc, poured into sat. NaHC03 solution (10 mL) and extracted with EtOAc (2 x 20 mL). Combined organics were dried over Na2S04, filtered and evaporated to dryness. The residue was purified by silica gel flash chromatography eluting with a 0 to 5% MeOH-DCM gradient to give the title compound (0.03 g, 48 %) as a colorless solid. MS: 425.4 (M+H+)., 2510-36-3
The synthetic route of 2510-36-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; HORNSPERGER, Benoit; KNUST, Henner; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; ZHOU, Mingwei; WO2013/37779; (2013); A1;,
Isoxazole – Wikipedia
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