With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3405-77-4,5-Methylisoxazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.
General procedure: To the appropriate acid derivative 7, (Jackson et al., 2012) 10 (0.021 mol) in 20 ml of THF, 3.6 g of N,N’-carbonyldiimidazol (CDI) was slowly added under stirring. After addition was complete, the solution was first magnetically stirred for 30 min at room temperature and then heated to 60 ¡ãC for 1 h. The reaction mixture was cooled to room temperature and treated with 2.3 g of MgCl2 and 4.5 g of ethyl potassium malonate. After stirring (r.t.) for 3 h 15 ml of water followed by 5 ml of HCl 6 N was added. The mixture was then concentrated under reduced pressure, and the obtained white solid was collected by filtration, washed with water, and dried. Spectroscopical and physical data of compound 11a are in accordance with those reported in the literature (Takagi et al., 2008)., 3405-77-4
As the paragraph descriping shows that 3405-77-4 is playing an increasingly important role.
Reference£º
Article; Cascioferro, Stella; Maggio, Benedetta; Raffa, Demetrio; Raimondi, Maria Valeria; Cusimano, Maria Grazia; Schillaci, Domenico; Manachini, Barbara; Leonchiks, Ainars; Daidone, Giuseppe; Medicinal Chemistry Research; vol. 25; 5; (2016); p. 870 – 878;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem