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Anti-inflammatory activity of Syzygium aromaticum silver nanoparticles: In vitro and in silico study
Objective: In the present study, antioxidant and anti-inflammatory activity of Syzygium aromaticum (clove) silver nanoparticles (clove AgNP?s) was evaluated. Methods: Gas chromatography-mass spectrometry technique was used to identify the compounds present in the aqueous extract of clove. Fourier transform infrared (FT-IR) analysis was done to characterize the clove silver AgNP?s. 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay was performed to evaluate the antioxidant property of nanoparticles (0.05 and 0.25 mg/ml) and aqueous extracts (0.05, 0.1, and 0.25 mg/ml) of clove. The antiinflammatory property of the clove AgNP?s was determined by inhibition of protein denaturation and downregulation of interleukin-1 beta. In silico molecular docking studies was performed using Schrodinger Maestro software. Results: Eugenol was found to be highest with 16.27%. The AgNP?s exhibited dose-dependent antioxidant property. AgNP?s scavenged 80% of radical at the concentration of 0.25 mg/ml. The scavenging activity of AgNP?s markedly increased when compared to aqueous extract at the same concentration. Inhibition of protein denaturation assay also revealed AgNP?s showing the highest activity (66%) when compared with drug aspirin (55%) and aqueous extract (56%). In the enzyme-linked immunosorbent assay (ELISA) method, AgNP?s showed better inhibition (80%) when compared to aqueous extract (60%). Among 15 compounds, two compounds (eugenol and methyl 14-methylpentadecanoate) showed good glide energy, docking score, and hydrogen-bonded active site interactions with the protein interleukin-1 beta. Conclusion: As AgNP?s were more active than the aqueous extract, it may be considered for pharmacological activity against inflammatory disorders.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 78967-07-4. In my other articles, you can also check out more blogs about 78967-07-4
Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem