1123-49-5, Name is 3,5-Dimethyl-4-nitroisoxazole, belongs to isoxazole compound, is a common compound. Application In Synthesis of 3,5-Dimethyl-4-nitroisoxazoleIn an article, once mentioned the new application about 1123-49-5.
Michael additions on isoxazole derivatives under solvent-free conditions
Knoevenagel condensation of 3,5-dimethyl-4-nitro-isoxazole 1 with aromatic aldehydes in solid state in the presence of piperidine gives 3-methyl-4-nitro-5-styryl-isoxazoles 2 in excellent yields within few minutes. Michael addition of active methylene compounds 3 to 2 in piperidine affords beta-diketones 4. Similarly 1 reacts with chalcones 5 in piperidine very efficiently to give Michael adducts 6 in excellent yields with substantial reduction in reaction time under solvent-free conditions.
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Reference：
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem