4369-55-5, 5-Amino-3-phenylisoxazole is a Isoxazoles compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a 100ml four-necked flask, 3-phenyl-5-aminoisoxazole and benzisothiazolin-3-one-2-yl acetic acid, Its molar ratio is 1:1.1, Dissolve with DMF (N,N-dimethylformamide), Adding HOBT (1-hydroxybenzotriazole) and EDCI [1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride], The molar ratio of HOBT, EDCI and 3-phenyl-5-aminoisoxazole was 1:1:1, and the reaction was completed at 25 ¡ã C for 26 h. The solution was poured into water and a large amount of solid was precipitated. Filtration, caustic washing, pickling, and washing. The crude product was obtained by column chromatography (ethyl acetate: petroleum ether = 1 : 1.1). Yield: 68.5percent. Melting point: 189 to 191 ¡ãC.
The synthetic route of 4369-55-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Nanjing Tech University; Yu Peng; Liu Biming; Pan Jian; Li Xi; Xu Yanhua; (10 pag.)CN109535153; (2019); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem