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Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity
The biphenyl amides (BPAs) are a novel series of p38alpha MAP kinase inhibitor. The optimisation of the series to give compounds that are potent in an in vivo disease model is discussed. SAR is presented and rationalised with reference to the crystallographic binding mode.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem