33282-15-4, Name is 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acid, belongs to Isoxazoles compound, is a common compound. name: 5-(4-Hydroxyphenyl)isoxazole-3-carboxylic acidIn an article, once mentioned the new application about 33282-15-4.
Improved synthesis and reaction of 11-chloroneocryptolepines, strategic scaffold for antimalaria agent, and their 6-methyl congener from indole-3-carboxylate
Various 11-chloro-5-methyl-5H-indolo[2,3-b]quinolines (neocryptolepines) with different substituents on the quinoline ring, key intermediates for antimalaria agents, are prepared from the substituted N-methylanilines, easily accessible by the N-methylation of anilines, and indole-3-carboxylate as a counterpart. This protocol is benign in terms of the reduced number of steps to reach the target, compared with the known method using anilines, and easy product purification. Alternatively, their 6-methyl congener is prepared by N-methylation of the indole moiety of 2-arylaminoindole-3-carboxylate followed by successive cyclization and chlorination. 11-Chloroneocryptolepines are found more reactive than their 6-methyl congener in the nucleophilic substitution at the C11 position.
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Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem