Properties and Exciting Facts About 288-14-2

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: Isoxazoles, you can also check out more blogs about288-14-2

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: Isoxazoles. Introducing a new discovery about 288-14-2, Name is Isoxazole

Synthesis, characterization, biological activities and molecular modeling of Schiff bases of benzene sulfonamides bearing curcumin scaffold

Curcumin has shown large number of pharmacological properties against different phenotypes of various disease models. Different synthetic routes have been employed to develop its various derivatives for diverse biological functions. In this study Schiff bases of benzenes sulfonamides bearing curcumin scaffold were synthesized to investigate their pharmacological effects. The structures of newly synthesized compounds were described by IR, 1H NMR and 13C NMR spectral data. The anti-inflammatory and antinociceptive activities of new compounds were evaluated with indomethacin and diclofenac sodium in experimental animal models respectively. COX-2 enzyme inhibition was evaluated with synthesized compounds through in vitro cyclooxygenase assays. Inhibition assays result revealed that compound 3a was the most potent compound. Molecular docking studies were also performed to identify the plausible binding mode of this compound. Antibacterial and antifungal activities were evaluated with ciprofloxacin, nystatin and ketoconazole using disk diffusion method and minimum inhibitory concentration values were determined by 96-well plate assay method. Our studies showed that compound 3a has promising antibacterial and anti-inflammatory while 3c has better antifungal activity as compared to reference drugs. Similarly the combination of more potent compounds 3a and 3c with ciprofloxacin and nystatin respectively gave significant synergic effect.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: Isoxazoles, you can also check out more blogs about288-14-2

Reference£º
Isoxazole – Wikipedia,
Isoxazole | C3H3NO – PubChem