With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62348-13-4,Isoxazole-5-carbonyl chloride,as a common compound, the synthetic route is as follows.
Benzo[b]thiophene-6-ol (Compound 1) (5.86 g, 39.01 mmol) under a nitrogen atmosphereAfter 4-dimethylaminopyridine DMAP (473 mg, 3.87 mmol) was dissolved together in THF (100 mL),Additional triethylamine (4.15 g, 41.03 mmol) and isoxazole-5-acyl chloride (Compound 2) (40.99 mmol),The mixture was heated to reflux for 7 hours and then the reaction was cooled to 50 C.A mixture of water (20 mL) and acetic acid (3.67 mL) was added to give a layered solution.The organic layer is separated and the aqueous layer is discarded to obtain a solution of benzo[b]thiophene-6-isoxazole-5-carboxylate (compound 3) in THF.This solution was used directly in the next step of the synthesis.
62348-13-4 Isoxazole-5-carbonyl chloride 2736707, aIsoxazoles compound, is more and more widely used in various.
Reference£º
Patent; Wang Liping; (11 pag.)CN108558852; (2018); A;,
Isoxazole – Wikipedia
Isoxazole | C3H3NO – PubChem