Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 22264-50-2, Name is 1-Amino-1-cyclobutanecarboxylic acid, molecular formula is C5H9NO2, belongs to Isoxazoles compound, is a common compound. In a patnet, author is Hamama, W. S., once mentioned the new application about 22264-50-2, Product Details of 22264-50-2.
Synthesis and Biological Evaluation of Some Novel Isoxazole Derivatives
The reaction of 5-amino-3- methylisoxazole (1) with formalin and secondary amines gave the corresponding Mannich bases 3-6. Alkylation of isoxazole derivative 1 with Mannich bases hydrochloride gave unsubstituted isoxazolo[5,4-b] pyridine derivatives 8a, b via alkylation at position 4. Moreover, coupling reaction of 1 with different diazonium salts gave the corresponding mono and bisazo dyes of isoxazole derivative. The newly synthesized compounds were screened for their antitumor activity compared with 5-fluorouracil as a wellknown cytotoxic agent using Ehrlich ascites carcinoma cells. Interestingly, the obtained results showed clearly that compounds 3, 15, 8b, 4, 8a, and 5 exhibited high antitumor activity than 5-fluorouracil.
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Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem