Let¡¯s face it, organic chemistry can seem difficult to learn, SDS of cas: 57294-38-9, Especially from a beginner¡¯s point of view. Like 57294-38-9, Name is Boc-GABA-OH, molecular formula is Isoxazoles, belongs to Isoxazoles compound. In a document, author is Kletskov, Alexey V., introducing its new discovery.
Synthesis and Biological Activity of Novel Comenic Acid Derivatives Containing Isoxazole and Isothiazole Moieties
Methyl 5-hydroxy-4-oxo-4H-pyran-2-carboxylate was synthesized by esterification of methanol with comenic acid under acidic catalysis. The obtained ester was alkylated with 3-(chloromethyl)-5-phenylisoxazole and 4,5-dichloro-3-(chloromethyl)isothiazole to afford corresponding conjugates containing isoxazole and isothiazole moieties which then were transformed into water-soluble Li-salts. During the bioassays of synthesized isoxazole and isothiazole derivatives of comenic acid in mixtures with first-line antitumor drug Temobel (Temozolomid) used in brain tumors chemotherapy, a synergetic effect was observed.
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Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem