In an article, author is Bottorff, Shalina C., once mentioned the application of 22264-50-2, Recommanded Product: 1-Amino-1-cyclobutanecarboxylic acid, Name is 1-Amino-1-cyclobutanecarboxylic acid, molecular formula is C5H9NO2, molecular weight is 115.1305, MDL number is MFCD00661068, category is Isoxazoles. Now introduce a scientific discovery about this category.
Cu-Free 1,3-Dipolar Cycloaddition Click Reactions To Form Isoxazole Linkers in Chelating Ligands for fac-[M-I(CO)(3)](+) Centers (M = Re, Tc-99m)
Isoxazole ring formation was examined as a potential Cu-free alternative click reaction to Cu-I-catalyzed alkyne/azide cycloaddition. The isoxazole reaction was explored at macroscopic and radiotracer concentrations with the fac-[M-I(CO)(3)](+) (M = Re, Tc-99m) core for use as a noncoordinating linker strategy between covalently linked molecules. Two click assembly methods (click, then chelate and chelate, then click) were examined to determine the feasibility of isoxazole ring formation with either alkyne-functionalized tridentate chelates or their respective fac-[M-I(CO)(3)](+) complexes with a model nitrile oxide generator. Macroscale experiments, alkyne-functionalized chelates, or Re complexes indicate facile formation of the isoxazole ring. Tc-99m experiments demonstrate efficient radiolabeling with click, then chelate; however, the chelate, then click approach led to faster product formation, but lower yields compared to the Re analogues.
If you are interested in 22264-50-2, you can contact me at any time and look forward to more communication. Recommanded Product: 1-Amino-1-cyclobutanecarboxylic acid.
Reference:
Isoxazole – Wikipedia,
,Isoxazole | C3H3NO – PubChem